HORDB

ID: hor003296
Uniprot ID: O35417
Protein name: Dynorphin A(1-13)
Gene name: Pdyn
Organism: Mus musculus (Mouse)
Family: Opioid neuropeptide precursor family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001515 opioid peptide activity; GO:0005184 neuropeptide hormone activity; GO:0031628 opioid receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007600 sensory perception
GO CC: GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus; GO:0098686 hippocampal mossy fiber to CA3 synapse; GO:0098992 neuronal dense core vesicle; GO:0099013 neuronal dense core vesicle lumen

Sequence: YGGFLRRIRPKLK
Length: 13(202-214)
Propeptide: MAWSRLMLAACLLVMPSNVMADCLSLCSLCAVRIQDGPRPINPLICSLECQDLVPPSEEWETCRGFSSFLTLTVSGLRGKDDLEDEVALEEGISAHAKLLEPVLKELEKSRLLTSVPEEKFRGLSSSFGNGKESELAGADRMNDEAAQGRTVHFNEEDLRKQAKRYGGFLRKYPKRSSEMARDEDGGQDGDQVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQENPNTYSEDLDV
Signal peptide: MAWSRLMLAACLLVMPSNVMA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
Mechanism: NA
Cross BBB: YES
Target: Oprk1
Target Unid: P33534
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003296_AF2.pdb

hor003296_ESM.pdb

Mass:	181819	Formula:	C75H126N24O15
Absent amino acids:	ACDEHMNQSTVW	Common amino acids:	R
pI:	12.25	Basic residues:	5
Polar residues:	3	Hydrophobic residues:	4
Hydrophobicity:	-77.69	Boman Index:	-3638
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	90
Instability Index:	7282.31	Extinction Coefficient cystines:	1490
Absorbance 280nm:	124.17